In 2005, Key Wane met rapper Big Sean, who was friends with his older brother and cousin at their high school, Cass Technical High School in Detroit. Around the same time Wane started taking record production seriously, and begun sending him beats periodically. During mid-2010 before his junior year of college, Key Wane first became known after producing “Memories” by Big Sean, from his third mixtape Finally Famous Vol. 3: BIG.
In 2011, Key Wane received his first big beat placement outside of a Big Sean project, producing Tyga’s “Drink the Night Away” featuring The Game and Mario, “Don’t Wake Me Up” and “Hypnotized”, all of which featured on his mixtape Black Thoughts Vol. 2. In November 2011, Big Sean signed Wane to a co-publishing deal with his record label Finally Famous as a song-writer and record producer. He would be the first producer signed to Sean’s Finally Famous record label, which also includes rappers Earlly Mac and SAYITAINTTONE.
In early 2012, Key Wane produced the controversial track “Amen” originally for Big Sean, but after he passed on it Meek Mill picked it up and would release it as the lead single from his debut album Dreams and Nightmares. Many Christian hip hop artists and religious leaders commented negatively on the song. However the song would end up peaking at number 57 on the Billboard Hot 100. After his significant contributions over the year such as to Sean’s “Guap” and Detroit mixtape, XXL named Key Wane one of hip-hops most must-watch producers.
In September 2012, Key Wane revealed upcoming collaborations with Trey Songz, Hit-Boy, King Chip, Rockie Fresh. Then in December 2012, Wane confirmed working with Drake, Jhene Aiko, Big Sean and Beyoncé on their upcoming albums. On February 4, 2013 Wane released his second mixtape, titled So Many Keys Vol. 1. It was primarily a collection of his most known produced songs, along with a new solo track “Have Some Fun”. On August 1, 2013 Drake released a song titled “All Me” produced by Key Wane, featuring 2 Chainz and Big Sean, from his upcoming third studio album Nothing Was the Same. He had origionlly produced the instrumental for Big Sean, but after the record had sat for a couple months he sent the instrumental to Drake, who immediately picked up the beat. Along with No ID, Key Wane produced the majority of Big Sean’s second studio album Hall of Fame (2013), including the highest charting singles of the album, “Guap” and “Beware” featuring Jhene Aiko and Lil Wayne. He contributed production to six songs in total. On December 22, 2013, Diggy Simmons released a song named “Mama Said”, featuring vocals from B.o.B and Key Wane. Key Wane also provided the song’s production.